Research Publications
- Recent Discoveries of Mechanisms Contributing to Necrotizing Enterocolitis
Necrotizing enterocolitis (NEC) is a devastating neonatal intestinal disease driven by complex interactions between prematurity, microbial dysbiosis, immune dysregulation, and impaired intestinal barrier function. This article highlights recent advances in NEC pathogenesis, focusing on the role of […]
- Elevating Patient-Family Voices in Necrotizing Enterocolitis
A diagnosis of necrotizing enterocolitis (NEC) often affects families for a lifetime. Given the profound burden of NEC, families are uniquely positioned to harness the power of their experience to advocate for and contribute to research. Clinicians and scientists can also collaborate with families […]
- Eliminating Disparities and Optimizing Equity in Necrotizing Enterocolitis
Necrotizing enterocolitis is a devastating complication of prematurity with high mortality and lifelong morbidities. The burden of disease is inequitably distributed, with higher incidence and mortality in racialized, socioeconomically disadvantaged, and geographically marginalized populations. […]
- Donor Milk: Practical Considerations for Necrotizing Enterocolitis Reduction
The practical considerations for using pasteurized donor human milk (PDHM) require a standardized yet individualized approach. Mother's own milk should be prioritized with PDHM serving as a bridge. Neonatal intensive care unit should focus on early feeding and a base diet of human milk MOM […]
- Promising Treatments and Novel Therapeutic Approaches for the Management of Necrotizing Enterocolitis
Necrotizing enterocolitis (NEC) is a deadly intestinal disease that most commonly occurs in premature infants. Current treatments are reactive rather than preventative, and include feeding cessation, antibiotics, gastric decompression, and supportive care. In severe NEC, surgical intervention is […]
- Scaling and Spreading Implementation Strategies for Prevention of Necrotizing Enterocolitis
The primary focus in advancing necrotizing enterocolitis (NEC) has been on prevention as there have not been major breakthroughs in novel biomarkers or therapeutics, likely due to the multiple etiologies that lead to NEC and its rapidity of onset. Many opportunities to prevent NEC exist in tested […]
- Emerging Tools and Biomarker Approaches to Understand and Diagnose Necrotizing Enterocolitis
Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease primarily affecting preterm infants and is associated with a high mortality and long-term morbidity. Despite decades of research, NEC pathogenesis remains incompletely understood, and early diagnosis is challenging. NEC is a […]
- Different Perspectives in Defining Necrotizing Enterocolitis
Establishing a definition for necrotizing enterocolitis has been a goal for the past 50 or more years. Many definitions and diagnostic criteria have been proposed, including the commonly used Bell staging. There are notable similarities and differences between published criteria, but uncertainty as […]
- Collaborating Towards a World Without Necrotizing Enterocolitis
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- Definitions of neonatal Necrotizing Enterocolitis (NEC) in randomised controlled trials: a systematic review
CONCLUSIONS: There is consistent use of Bell's and Modified Bell's criteria of necrotizing enterocolitis in RCTs. However, international consensus on further modifications of the definition will greatly contribute to both research and clinical practice relating to NEC, in allowing greater […]
- Cumulative Opioid Exposures in the First Year of Life and Cognitive Neurodevelopment in High-Risk Infants
CONCLUSION: Higher cumulative opioid exposure in the first year of life was associated with reduced cognitive scores at 18 months or older, independent of comorbidities. Opioid stewardship initiatives extended to high-risk infants may further optimize long-term neurodevelopment.
- Probiotic-Associated Infection vs Necrotizing Enterocolitis-Weighing Risks and Benefits
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- Artificial intelligence for the diagnosis and surgical prognosis of necrotizing enterocolitis
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- A randomized trial of an exclusive human milk diet in neonates with single-ventricle physiology: 3 and 6 months follow-up outcomes
CONCLUSIONS: Neonates with SVP receiving an EHM diet from birth to 30 days post-surgery had similar growth at 3-6 months of age compared to the control diet. Infants with SVP benefit from a protocolized nutritional approach, as evidenced by normal growth velocities in infancy. Centers may consider […]
- "Necrotizing enterocolitis": a paradigm shift
Necrotizing enterocolitis (NEC) reveals substantial heterogeneity in presentation and underlying mechanisms. Conventional diagnostic tools, especially radiographic criteria and Bell staging, fail to distinguish between biologically distinct forms of intestinal injury, leading to imprecise […]