Research Publications
- Definitions of neonatal Necrotizing Enterocolitis (NEC) in randomised controlled trials: a systematic review
CONCLUSIONS: There is consistent use of Bell's and Modified Bell's criteria of necrotizing enterocolitis in RCTs. However, international consensus on further modifications of the definition will greatly contribute to both research and clinical practice relating to NEC, in allowing greater […]
- Cumulative Opioid Exposures in the First Year of Life and Cognitive Neurodevelopment in High-Risk Infants
CONCLUSION: Higher cumulative opioid exposure in the first year of life was associated with reduced cognitive scores at 18 months or older, independent of comorbidities. Opioid stewardship initiatives extended to high-risk infants may further optimize long-term neurodevelopment.
- Probiotic-Associated Infection vs Necrotizing Enterocolitis-Weighing Risks and Benefits
No abstract
- Artificial intelligence for the diagnosis and surgical prognosis of necrotizing enterocolitis
No abstract
- A randomized trial of an exclusive human milk diet in neonates with single-ventricle physiology: 3 and 6 months follow-up outcomes
CONCLUSIONS: Neonates with SVP receiving an EHM diet from birth to 30 days post-surgery had similar growth at 3-6 months of age compared to the control diet. Infants with SVP benefit from a protocolized nutritional approach, as evidenced by normal growth velocities in infancy. Centers may consider […]
- "Necrotizing enterocolitis": a paradigm shift
Necrotizing enterocolitis (NEC) reveals substantial heterogeneity in presentation and underlying mechanisms. Conventional diagnostic tools, especially radiographic criteria and Bell staging, fail to distinguish between biologically distinct forms of intestinal injury, leading to imprecise […]
- Inhibition of DNA demethylation attenuates experimental necrotizing enterocolitis via suppression of TLR4-mediated inflammation
CONCLUSIONS: These findings advance our understanding of the role of abnormal DNA demethylation in NEC development. Moreover, our results demonstrate that a DNA demethylation inhibitor attenuates experimental NEC by decreasing TLR4-driven immune responses and intestinal inflammation. Targeting DNA […]
- Correction: Probiotics and necrotizing enterocolitis in preterm infants after the food and drug administration warning actions
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- Encapsulation enhances stromal cell survival for safe neonatal therapy: a pilot study
CONCLUSION: Encapsulation within the THRED preserves MSC viability and identity in vivo. This approach provides a clinically practical method to deliver MSC therapy during initial NEC surgery or drain placement with retrieval at a later procedure. This serves as a proof-of-concept and offers a […]
- Developing a prioritized research agenda for necrotizing enterocolitis
CONCLUSIONS: The top 6 research topics, identified collaboratively through patient-family and clinician-researcher partnerships, should be prioritized by scientists, administrators, funders, policymakers, and others to accelerate research meaningful to NEC stakeholders.
- Triglyceride profiles in preterm infants reveal dynamic and age-specific trajectories
INTRODUCTION: Triglyceride (TG) values are routinely monitored in preterm infants receiving lipid emulsion therapy, but their clinical utility remains poorly defined. The objective of this study was to define TG values and their associations with gestational age (GA), birth weight (BW), lipid […]
- Red Blood Cell Transfusion Characteristics and Morbidity or Mortality in Very-Low-Birth-Weight Infants
CONCLUSIONS AND RELEVANCE: In this cohort study of VLBW infants, pretransfusion hemoglobin and anticoagulant preservative solution were associated with a composite of morbidities and mortality, unlike other modifiable blood banking practices. For individual outcomes, select donor and blood banking […]
- Current operative approaches for necrotizing enterocolitis
Necrotizing enterocolitis is an overwhelming, catastrophic gastrointestinal disease largely affecting premature infants. The disease is manifested by exaggerated intestinal inflammation, which can progress to necrosis of the bowel and systemic sepsis. Prognosis is poor, with unacceptably high […]
- Probiotics and necrotizing enterocolitis in preterm infants after the food and drug administration warning actions
CONCLUSION: NEC incidence increased in centers routinely using probiotics after rapid cessation of use following FDA actions.
- Urolithin A attenuates inflammation and enhances barrier integrity in an experimental NEC-in-a-Dish model
CONCLUSION: UroA reduces inflammation and strengthens epithelial barrier integrity in a NEC-in-a-Dish model through a variety of mechanisms. These findings support further investigation of dietary-derived metabolites as potential preventative strategies for NEC in preterm infants.