David J. Hackam, M.D., Ph.D.

Johns Hopkins

http://www.hopkinsmedicine.org/pediatricsurgery/research/hackam_lab/

Research Interests

Basic and translational mechanisms leading to the development of NEC, with a focus on microbial and host interactions, genetic influences and maternal-fetal interactions.

Current NEC research projects
1. Role of toll like receptor signaling in the pathogenesis and prevention of NEC
2. Gut-lung interactions in NEC
3. Properties of milk that prevent and treat NEC in children
4. Gut and lung stem cells in the pathogenesis and treatment of NEC

Recent Publications

1. Good M, Sodhi CP, Egan CE, Afrazi A, Jia H, Yamamaguchi Y, Lu P, Branca MF, Ma C, Prindle The, Mielo S, Pompa A, Hodzic Z, Ozolek JA, Hackam DJ. Breast Milk Protects Against The Development Of Necrotizing Enterocolitis Through Inhibition Of Toll Like Receptor 4 In The Intestinal Epithelium Via Activation Of The Epidermal Growth Factor Receptor. Mucosal Immunology 2015 8(5):1166-79. Featured manuscript on the journal website (http://www.nature.com/mi/index.html)

2. Sodhi CP, Jia HH, Yamaguchi Y, Lu P, Good M, Egan C, Ozolek J, Zhu X, Billiar TR, Hackam DJ. Intestinal epithelial Toll-like Receptor-4 activation is required for the development of acute lung injury after trauma/hemorrhagic shock via the release of HMGB1 from the gut. J Immunol 2015 194(1):4931-9.

3. Buchholz BM, Shapiro RA, Vodovotz Y, Billiar TR, Sodhi CP, Hackam DJ, Bauer AJ. Myocyte TLR4 enhances enteric and systemic inflammation driving late murine endotoxic ileus. American Journal of Physiology Gastrointestinal & Liver Physiology 2015, 308(10):G852-62.

4. Wipf P, Eyer BR, Yamaguchi Y, Zhang F, Neal MD, Sodhi CP, Good M, Branca M, Prindle The, Lu P, Brodsky JL, Hackam DJ. Synthesis of anti-inflammatory a- and b-linked acetamidopyranosides as inhibitors of toll like receptor 4 (TLR4). Tetrahedron Lett. 2015, 56(23):3097-3100.

5. Shaffiey SA, Jia H, Keane T, Costello C, Wasserman D, Quidgley M, Dziki J, Badylak S, Sodhi CP, March JC, Hackam DJ. Intestinal stem cell growth and differentiation on a tubular scaffold with evaluation in small and large animals. Regen Med 2016, 11 (1):45-61

6. Cai J, Yuan H, Wang Q, Yang H, Al-Abed Y, Hua Z, Wang J, Chen D, Wu J, Lu B, Pribis JP, Jiang W, Yang K, Hackam DJ, Tracey KJ, Billiar TR, Chen AF. HMGB1 driven inflammation and intimal hyperplasia after arterial injury involves cell-specific actions mediated by TLR4. Arterioscler Thromb Basc Biol 2015, 35(12), 2579-93

7. Deng M, Ma T, Yan Z, Zettel KR, Scott MJ, Liao H, Frank A, Morelli AE, Sodhi CP, Hackam DJ, Billiar TR. Toll like receptor 4 signaling on dendritic cells suppresses polymorphonuclear leukocyte CXCR2 expression and trafficking via interleukin 10 during intra-abdominal sepsis. J Infect Disease, 2016 15;213(8):1280-8.

8. Fritz M, Klawonn AM, Nilsson A, Singh AK, Zajdel J, Björk Wilhelms D, Lazarus M, Löfberg A, Jaarola M, Örtegren Kugelberg U, Billiar TR, Hackam DJ, Sodhi CP, Breyer MD, Jakobsson J, Schwaninger M, Schütz G, Rodriguez Parkitna J, Saper CB, Blomqvist A, Engblom D. Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation induced aversion in mice. J Clin Invest 2016 126(2):695-705.

9. Egan CE, Sodhi CP, Good M, Lin J, Jia H, Yamaguchi Y, Lu P, Ma C, Branca MF, Weyandt S, Fulton WB, Niño DF, Prindle T Jr, Ozolek JA, Hackam DJ. Toll like receptor 4 mediated lymphocyte influx induces neonatal necrotizing enterocolitis. J Clin Invest 2016, 126(2):495-508.

10. Cunningham KE, Vincent G, Sodhi CP, Novak EA, Ranganathan S, Egan CE, Stolz DB, Rogers MB, Firek B, Morowitz MJ, Gittes GK, Zuckerbraun BS, Hackam DJ, Mollen KP. Peroxisome proliferator-activated receptor gamma coactivator 1a (PGC1a) protects against experimental murine colitis. J Biol Chem 2016 6;291(19):10184-200

11. Jia H, Sodhi CP, Yamaguchi Y, Lu P, Martin LY, Good M, Zhou Q, Sung J, Fulton WB, Nino DF, Prindle T Jr, Ozolek JA, Hackam DJ. Pulmonary epithelial TLR4 activation leads to lung injury in neonatal necrotizing enterocolitis. J Immunol 2016, 197(3):859-71, also listed as a featured article on J Immunol website).

12. Good M, Sodhi CP, Yamaguchi Y, Jia H, Lu P, Fulton W, Martin L, Prindle T Jr., Nino D, Zhou Q, Ma Q, Ozolek JA, Buck RH, Goehring KC, and Hackam DJ. The human milk oligosaccharide 2-fucosyllactose attenuates the severity of experimental necrotizing enterocolitis by enhancing mesenteric perfusion in the neonatal intestine. British Journal of Nutrition (in press).

13. Nino DF, Sodhi CP, Egan CE, Zhou Q, Lin J, Lu P, Yamaguchi Y, Jia H, Martin, Good M, Fulton, WB, Prindle T, Ozolek JA, Hackam DJ. Retinoic acid improves incidence and severity of necrotizing enterocolitis by lymphocyte balance restitution and repopulation of Lgr5 intestinal stem cells. Shock 2016 (in press).

Reviews: 1. Nino D, Sodhi C, Hackam DJ. Necrotizing enterocolitis. Nature Reviews Gastroenterology and Hepatology (in press)

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