Beth Israel Deaconess Medical Center-Harvard Medical School; Associate Professor of Pediatrics; Associate Director NICU
The role of nutrient sensing in intestinal development (organogenesis, establishment of the microbiome, immune function) and vulnerability to intestinal injury. Our lab uses multiple animal models as well as draws upon a large infant biorepository for hypothesis testing and elucidation of mechanisms.
Currently we are using multiomic strategies to understand fat metabolism and its role in postnatal intestinal health. This includes bioactive factors in major lipid classes, fatty acids, metabolic intermediates, and down stream pro-resolving mediators which our lab has shown also participates in organogenesis during the neonatal period.
Martin CR, Cheesman A, Brown J, Makda M, Kutner AJ, DaSilva D, Zaman M, Freedman SD. Factors Determining Optimal Fatty Acid Absorption in Preterm Infants. J Pediatr Gastroenterol Nutr. 2016 Jan;62(1):130-6.
Tao GZ, Liu B, Zhang R, Liu G, Abdullah F, Harris MC, Brandt ML, Ehrenkranz RA, Bowers C, Martin CR, Moss RL, Sylvester KG. Impaired Activity of Blood Coagulant Factor XIII in Patients with Necrotizing Enterocolitis. Sci Rep. 2015 Aug 17;5:13119.
Konnikova Y, Zaman MM, Makda M, D’Onofrio D, Freedman SD, Martin CR. Late Enteral Feedings Are Associated with Intestinal Inflammation and Adverse Neonatal Outcomes. PLoS One. 2015 Jul 14;10(7):e0132924.